SiROP opportunities [D-CHAB,D-BIOL,VCS]

Master Thesis: Building a 25 MHz NMR spectrometer
A Master project starting in Autumn/Winter 2024/2025 is available in the group of Prof. Roland Riek, Laboratory for Physical Chemistry (D-CHAB). The student will build a 25 MHz Nuclear Magnetic Resonance (NMR) spectrometer. The spectrometer console will run on a compact board (SDR Lab, Red Pitaya) [1]. A permanent magnet will (10 x 10 x 10 cm3) generate a field of 0.6 T, corresponding to a 1H NMR frequency of 25 MHz.
BSc or MSc Thesis, Research Project, Hilfsassiste in an ETH startup
Diaxxo (diaxxo.com) is a start-up originated at ETH Zürich, where in the past 4 years we have developed and prototyped an innovative Point-of-Care Polymerase Chain Reaction (PCR) device. Our vision is to bring the power of molecular diagnostics to every doctor’s office, thanks to our new pre-loaded PCR test kits that allow for simpler and faster sample preparation steps. In 2020 our devices have been used by more than 250 laypeople for the rapid detection of COVID-19 in a field study that we run at ETH Zürich, and our systems are currently being tested at the Swiss Tropical and Public Health Institute (Swiss TPH).
Inline Quality Control with image analysis & AI
diaxxo, a start-up from ETH Zürich, is revolutionizing molecular diagnostics with a cutting-edge Point-of-Care PCR device. Their innovative technology facilitates rapid, accurate diagnostic testing across human, veterinary, and food applications, especially in developing countries. The PCR process amplifies DNA sequences to identify pathogens accurately. Key to diaxxo's system are specialized aluminum cartridges containing pre-loaded, dried reagents, essential for precise diagnostics. However, current manufacturing challenges in reagent loading and drying affect cartridge quality. The project aims to develop a Quality Control station using advanced imaging and AI to ensure accurate reagent placement and drying, enhancing diagnostic reliability and effectiveness.
UX/UI development
diaxxo, a start-up from ETH Zürich, is transforming molecular diagnostics with its innovative Point-of-Care PCR device, aimed at providing accessible and reliable diagnostics globally. To enhance user interaction, this project focuses on developing a fully functional frontend for diaxxo's PCR diagnostic device, starting from an existing Figma prototype. The project goals include building an operational GUI that accurately reflects the prototype's design, enhancing user experience through feedback and usability testing, ensuring seamless backend integration, and providing detailed documentation. This project aims to improve the overall user experience and functionality of the device's interface, making it intuitive and efficient for both routine operations and development tasks.
Hardware development in medtech startup
diaxxo, a start-up from ETH Zürich, is transforming molecular diagnostics with an innovative Point-of-Care Polymerase Chain Reaction (PCR) device. Designed to accelerate and democratize access to diagnostic testing, our cutting-edge technology can be used across various fields, from human diagnostics to vet and food testing. Our products are also tailored for use in developing countries and resource-limited settings, aiming to bring reliable diagnostics to every corner of the globe. The company offers several projects and thesis opportunities focusing on interfacing computer and camera systems (e.g. controlling Camera Pi from ESP microcontrollers, and integrating hardware and software components to address design and automation challenges.
Biology of the cell nucleus (Prof. Karsten Weis/Dr. Elisa Dultz)
General research topics of the lab: Nuclear organization, Intracellular transport between the nucleus and the cytoplasm, Nuclear pore structure and function, mRNA transport and degradation.
RNP assembly machineries (Prof. Stefanie Jonas)
We study the assembly of RNA-protein complexes (RNPs) in the nucleus of human cells at a molecular level.
Plant Biochemistry Group (Prof. Samuel C. Zeeman)
Our research team studies the pathways and regulation of plant metabolism with focus on the degradation of starch and how metabolism is controlled in response to changes in the environment and the developmental stage of the plant.