Identification of membrane protein-protein interaction
This project is focused on exploring methods of detection of the cellulose synthase complex within the Golgi apparatus in Arabidopsis. The proposed work involves establishment and application of immuno-precipitation of membrane-solubilized protein complex.
The role of cryptic genetic variation on circadian behaviors
Cryptic genetic variation (CGV) is the hidden genetic variation accumulated over time that do not contribute to the normal range of phenotypes, but may provide a source of adaptive variation to novel conditions.
CRISPR/Cas9-mediated SNP changes to elucidate cause of size variations
How genetic variation (e.g. SNP) leads to different traits/phenotypes in natural populations is a fundamental and challenging problem in both the life and medical sciences. This project will involve several objectives to tackle this problem.
Interplay of posttranslational modification sites in enzyme activity regulation
For this project, we have selected different previously detected PTMs on four central metabolic enzymes. Using the CRISPR/Cas9 method, you will construct a library of strains with different combinations of mutations in these PTM sites.
Discovery of novel kinases in E. coli that regulate enzyme activity
In order to discover novel kinases, you will perform a series of physiological and metabolomics experiments with a set of suspected kinase mutants. To this end, you will complete growth experiments in microtiter plates and use untargeted mass spectrometry for metabolite measurements.
Investigating protein-metabolite interactions in E. coli
In this project, you will selectively perturb metabolite concentrations inside growing E. coli cells and characterize the dynamic metabolic response using state-of-the-art metabolomics techniques.
Biology of the cell nucleus (Prof. Karsten Weis)
General research topics of the lab: Nuclear organization, Intracellular transport between the nucleus and the cytoplasm, Nuclear pore structure and function, mRNA transport and degradation.
Mechanisms of asymmetric cell division (Prof. Yves Barral)
The laboratory studies the cell division process as a paradigm how cells control their spatio-temporal organization and coordinate complex architectural processes with each other.
DNA repair and Genome stability (Prof. Joao Matos)
Our group uses a combination of approaches (proteomics, biochemistry, cell biology and genetics) and model systems (budding yeast and human tissue culture) to investigate how cells rewire the recombination machinery.
Macromolecular machines mediating bacterial cell-cell interactions (Prof. Martin Pilhofer)
The lab investigates macromolecular complexes that generate order and bridge between the angstrom-scale of atoms, the nanometer-scale of macromolecular assemblies and the micron-scale of entire cells.
Computational single cell biology (Prof. Manfred Claassen)
We aim at elucidating the composition of heterogeneous cell populations and how these implement function in the context of cancer and immune biology by jointly evaluating single cell and genome wide measurements.
RNAi and Genome Integrity (Prof. Constance Ciaudo)
Determine the fundamental genetic/biochemical mechanisms that regulate genome integrity through the study of transposable elements and RNA interference pathways and by exploiting the ES cell system as an in vitro model for differentiation and development.

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