Probing the two-state reactivity of iron-oxo complexes: computational and/or experimental studies | |
Spin states play a significant role in defining the structure, reactivity, magnetic and spectroscopic properties of any molecule. Access to multiple spin states opens exciting possibilities in catalysis, the development of electronic devices, and even quantum computing. Metal catalysts may have access to several spin states, thus giving more leverage for reactivity tuning. Two similar reactions can proceed via two distinctively different mechanisms if they occur on potential energy surfaces with different spin multiplicities. In addition, under certain conditions, a reactant can cross over onto a surface with different spin multiplicity, thereby providing low energy paths for otherwise difficult processes. Such behavior is called two-state reactivity (TSR). Although TSR plays an essential role in organic synthesis and biology, its detailed understanding is limited. | |
Master Thesis: Building a 25 MHz NMR spectrometer | |
A Master project starting in Spring 2023 is available in the group of Prof. Roland Riek, Laboratory for Physical Chemistry (D-CHAB). The student will build a 25 MHz Nuclear Magnetic Resonance (NMR) spectrometer. The spectrometer console will run on a compact board (SDR Lab, Red Pitaya) [1]. A permanent magnet will (10 x 10 x 10 cm3) generate a field of 0.6 T, corresponding to a 1H NMR frequency of 25 MHz. | |
Single-Cell Image Data Analysis and Machine learning | |
The immune system plays a crucial role in protecting our body from foreign threats and infections. However, due to ineffective vaccines and pathogens evading the immune system this does not always work which results in many different disease such as chronic inflammation, Cancer, Virus infections. In order to find out why immune cells in our body are not capable of responding efficiently to identifying these threat, we are trying to uncover how each cell behaves when an immune response is triggered. We are doing this by encapsulating cells into individual droplets and observing their behaviour, such as the production of an antibody against a disease. Using this single-cell droplet technology approach, we are measuring in real-time from 10-100,000 cells for multiple of these functions such as Antibodies simultaneously creating large image datasets. In order to improve biology and medicine of the immune systems and the development of better vaccines, we need highly-trained algorithms to better extract relevant conclusions from the big data we generate from highly parallelized, multiplexed single cell experiments. To achieve this, we aim to further improve machine learning and objection detection as well as tracking based algorithms. | |
[Copy of] BSc or MSc Thesis, Research Project, Hilfsassiste | |
Diaxxo (diaxxo.com) is a start-up originated at ETH Zürich, where in the past 4 years we have developed and prototyped an innovative Point-of-Care Polymerase Chain Reaction (PCR) device. Our vision is to bring the power of molecular diagnostics to every doctor’s office, thanks to our new pre-loaded PCR test kits that allow for simpler and faster sample preparation steps. In 2020 our devices have been used by more than 250 laypeople for the rapid detection of COVID-19 in a field study that we run at ETH Zürich, and our systems are currently being tested at the Swiss Tropical and Public Health Institute (Swiss TPH). | |
BSc or MSc Thesis, Research Project, Hilfsassiste | |
Diaxxo (diaxxo.com) is a start-up originated at ETH Zürich, where in the past 4 years we have developed and prototyped an innovative Point-of-Care Polymerase Chain Reaction (PCR) device. Our vision is to bring the power of molecular diagnostics to every doctor’s office, thanks to our new pre-loaded PCR test kits that allow for simpler and faster sample preparation steps. In 2020 our devices have been used by more than 250 laypeople for the rapid detection of COVID-19 in a field study that we run at ETH Zürich, and our systems are currently being tested at the Swiss Tropical and Public Health Institute (Swiss TPH). | |
Single-Cell Epitope mapping using Antigen-libraries and single-cell secretion assays | |
This project uses droplet based microfluidics to encapsulate single-cells for antibody capture, characterization and B cell isolation. The current project involves cloning and expression of novel antigen into an antigen-library for antigen mapping at single-droplet resolution. The project is suited for Master projects and master thesis (>3 months) and involves, cloning, validation, expression analysis as well as single-droplet verification. Finally, antibody secretion experiment are planned to isolate single-antigen binders and B cell sequencing. Current antigens revolve around the SARS Cov2 Nucleocapsid protein, RBD and envelope proteins to assess antibody cross-reactivity. | |
Hilfsassistenz, BSc or MSc Thesis, Research Project | |
We are looking to hire a talented and hardworking student to work on some components of our innovative Polymerase Chain Reaction (PCR) devices. | |
Software Engineer - Innovative Lab Device for Diagnostics | |
Diaxxo is a start-up originated at ETH Zürich, where in the past years we have developed and prototyped an innovative Point-of-Care Polymerase Chain Reaction (PCR) device. Our vision is to bring the power of molecular diagnostics to every doctor’s office, thanks to our new pre-loaded PCR test kits that allow for simpler and faster sample preparation steps. Our systems are currently being used in several institutions in Europe and abroad. | |
Probing the biophysical and dynamic properties of single cells | |
Your project aims at the characterization of the biophysical properties of the cytoplasm of living mammalian cells. You will use a combination of novel single molecule imaging techniques that are currently at the latest stages of development in our group. The emphasis will be on single cell measurements that will allow to probe the dynamics and properties of the cytoplasm and how these changes in different physiological and pathological conditions. |
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