Identification of membrane protein-protein interaction
This project is focused on exploring methods of detection of the cellulose synthase complex within the Golgi apparatus in Arabidopsis. The proposed work involves establishment and application of immuno-precipitation of membrane-solubilized protein complex.
The role of cryptic genetic variation on circadian behaviors
Cryptic genetic variation (CGV) is the hidden genetic variation accumulated over time that do not contribute to the normal range of phenotypes, but may provide a source of adaptive variation to novel conditions.
CRISPR/Cas9-mediated SNP changes to elucidate cause of size variations
How genetic variation (e.g. SNP) leads to different traits/phenotypes in natural populations is a fundamental and challenging problem in both the life and medical sciences. This project will involve several objectives to tackle this problem.
Interplay of posttranslational modification sites in enzyme activity regulation
For this project, we have selected different previously detected PTMs on four central metabolic enzymes. Using the CRISPR/Cas9 method, you will construct a library of strains with different combinations of mutations in these PTM sites.
Discovery of novel kinases in E. coli that regulate enzyme activity
In order to discover novel kinases, you will perform a series of physiological and metabolomics experiments with a set of suspected kinase mutants. To this end, you will complete growth experiments in microtiter plates and use untargeted mass spectrometry for metabolite measurements.
Investigating protein-metabolite interactions in E. coli
In this project, you will selectively perturb metabolite concentrations inside growing E. coli cells and characterize the dynamic metabolic response using state-of-the-art metabolomics techniques.
Master/semester project at intersection of NMR spectroscopy, computational modeling and RNA biology
We are developing methods which combine NMR spectroscopy and computational techniques to gain insight into complex and dynamic biomolecular systems.
Feedback stabilization of a micro droplet in an optical trap
The project consists of building an optical trap and conducting position measure- ments of the droplet as a function of laser power. In a second step, a PID feedback loop will be implemented to actively stabilize the trap.

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