Mechano-regulation of bone repair and improvement of compromised defect healing
Delayed fracture repair and formation of non-unions is a major issue in orthopedic surgery. In order to better understand the complex mechanism of mechano-molecular regulation of fracture repair and to assess potential treatment approaches, we use standardized preclinical defect models in mice.
Development of a robotic endotracheal intubation system
The scope of this master project is the development of a first prototype to perform robot-assisted endotracheal intubation. This development includes the design of the system and its implementation for preliminary evaluation.
Development of a powder measuring method for additive manufacturing
Develop a method to measure and characterize the powder flow in the additive process DMD. A new optoelectronic test bench shall be developed, built, programmed and compared to the current measuring method.
Isolation of sarcoma circulating tumor cells
Establishment of an isolation method for sarcoma circulating tumor cells based on cell-matrix adhesion properties
Mechanical loading of bone defects with biomaterials
Bone injuries and defects requiring treatment are commonly treated with synthetic bone graft substitute. However, a current challenge is understanding how such voids and biomaterials influence the transfer of strain, and ultimately healing. This project aims to model such changes.
Projects on computer vision, state estimation, and machine learning for fixed-wing UAVs
If you are interested in computer vision and/or state estimation and/or machine learning in combination with UAVs, please send an e-mail to and attach your CV, grades & programming experience.
Master of Science in Chemistry and Physics of Soft Materials
The Adolphe Merkle Institute (AMI) is an independent competence center at the University of Fribourg that focuses on research and education in the domain of soft nanomaterials.This MSc programme provides a unique interdisciplinary curriculum in the field of Soft Materials.
Nonlinear optimization based Visual-Inertial SLAM on an embedded platform
This project aims at the development of a monocular visual-inertial state estimation pipeline based on nonlinear optimization capable of running on an embedded platform with limited computational resources.
Design of a Multi-Payload Adapter for a Small-Satellite Launch Vehicle
The main objective of this thesis is to design a multi-payload adapter-dispenser system for a small-satellite launch vehicle, which enables the concurrent launch of multiple smaller payloads in addition to one primary spacecraft.
Comparison of human cardiovascular circulation models for LVADs
We want to try and implement different cardiovascular models from literature on a common platform and perform comparison studies between them.
Experimental study of a blood pump impeller combining additive manufacturing with design automation
Additive manufacturing (AM) allows a fast and low cost production of functional prototypes, which can be tested at an early stage of the product development process. Especially for heart pumps, this approach is promising as a detailed fluid simulation of the blood flow requires complex models with high computational effort.
Automated creation of patched laminates simulation models
In this thesis, a method for the automated creation of patched laminates simulation models shall be developed.
Bone’s Interpretation of Local Mechanical Signals
The osteocyte lacunar network within bone is responsible for sensing mechanical signals, transducing them to biological signals, and orchestrating bone remodeling. Yet, the details of mechanical sensation are not understood and we must approach this topic computationally on the microscopic level.
Identifying the Nature of Mechanical Signalling in Bone
Although local tissue loading is probably the most important factor triggering bone remodelling, the nature of mechanical signalling is still elusive. The present study will compare different mechanical signals in bone attempting to identify the most realistic candidate.
Mechanical properties of electrospun single polymer nano-fibers.
Understanding micromechanical behavior of electrospun polymer networks through investigation of single nanofibers for intervertebral disc regeneration.
Design of a Casing for an Open-Source Activity Monitor
Design of a robust, comfortable and attractive casing for a commercial physical activity monitor, suitable for wearing on different locations on the body.
Real time biological and micromechanical characterisation of live spinal disk tissue for spinal disc repair and tissue engineering.
Real time micromechanical and microstructural characterisation of outer layers of intervertebral disc (annulus fibrosus) through 3D light imaging techniques for enhanced understanding of spinal disk biomechanics.
Novel electrospun scaffolds for spinal disc repair. Mechanics, biocompatibility and application.
Real time biomechanical characterisation of electrospun polymer scaffolds through 3D light imaging techniques for spinal repair.
Electrospun polymer nanofibers for tissue engineering and regenerative medicine.
Micromechanical and biological characterization of electro spun polycaprolactone nanofibers for tissue engineering scaffolds and regenerative medicine.
Design and manufacturing of a lightweight and cost-efficient exoskeleton hip component (AM/CFRP hybrid)
Combining additive manufacturing (AM) with carbon fiber reinforced plastics (CFRP) makes it possible to create novel lightweight structures. In case of an exoskeleton, such a hybrid approach can be utilized to manufacture an individualized, lightweight hip component.
Can intuitive user interaction be quantified with mobile eye tracking?
Eye Tracking Study in collaboration with medtech Startup. Quantifying intuitive user interaction with Mobile Eye Tracking.
Additive Manufacturing (AM) of hybrid structures
AM has opened a wide range of possibilities in producing function driven parts. Being able to produce complex structures has already shown to be promising. Still the production is facing problems as the need for support structures and post processes.
Immunotherapy of canine brain cancer
We are collaborating with veterinary clinics to launch an interventional trial in dogs bearing spontaneous, naturally occuring gliomas. We plan to combine IL-12Fc with checkpoint blockade. To this end we will test human checkpoint inhibitors for their functionality on canine lymphocytes.
3D bioprinting cell-laden silk fibroin scaffolds for bone tissue engineering
Three dimensional (3D) bioprinting is a promising approach to form tissue engineered constructs via positioning biomaterials, either alone or combined with growth factors, and/or cells, with controlled spatial distribution. Also, 3D bioprinted tissue engineered constructs provide practical means for studying cell behaviours in a 3D environment closely resembling physiologically-relevant conditions. In this project, we are aiming at printing cell-laden hydrogel scaffolds for bone regeneration.
Additive Manufacture Urban Farming Pods
With the increasing global population putting a strain on resources, the world is looking for new and innovative approaches to provide the population with sustenance that do not devastate the environment.
Inductive heating of continuous CFRP loop
This thesis shall investigate the inductive heating capability of a continuous prepreg CFRP loop for preforming purposes. Relevant process parameters shall be evaluated during experimental tests and equipment and process requirements shall be defined.
The emergence of subjective feelings during foraging under predation threat
Non-human approach-avoidance conflict tests are classic paradigms to elicit anxiety-like behaviours, and mimick aspects of foraging for food while under threat of predation. We have recently translated this class of paradigms to humans (e. g. Bach et al. 2014, Current Biology; Korn et al. 2017, Biological Psychiatry). However, it is unclear how behaviour in this paradigm relates to subjective feeling.
Super-Resolution MRI
Master thesis in physics or biomedical engineering involving the development of a novel Magnetic Resonance Imaging method based on super-resolution optics. The project includes theoretical, experimental and processing tasks - an excellent opportunity to get acquainted with modern MRI technology.
Research Positions (PhD and PostDoc)
The Institute for It Security at University of Lübeck is looking to fill two full-time research positions for research in system security and applied cryptography: • Post-Doctoral Researcher (Reference code 1040/17) • Research assistant (PhD level) – (Reference code 1041/17)
FlyDeep: Image-based count and size determination of insect larvae for waste bioconversion with deep learning
We will develop a deep-learning approach to count and estimate the size of insect larvae in images to benefit waste treatment in developing countries.
Segmentation of Geometrical Shapes in Aerial Images
We seek novel deep learning methods that transfer dense input data (images) to sparse output representations directly. The objective is to directly predict polygons (e.g., maps) from images (e.g., aerial images).
Optimization of a combined thermo-mechanical drilling method
The exploitation of deep geothermal resources relies on finding cost-effective solutions to increase the drilling performance in hard crystalline rocks. In this project, a combination of conventional drilling and thermal spallation drilling technologies shall be optimize.
Data Analysis Tool for ex-vivo perfused pig liver experiments
Regenerating a pig-liver outside of the body.
Master thesis proposal: Predicting companies success with the help of online ratings
The brick-and-mortar financial industry is becoming under pressure from its e-commerce and increasingly non-financial competitors. Customers request an increasingly more extensive and better service. This project is about building the foundation of such a service.
Development and testing an additive manufactured (AM) volume flow measuring unit
- Volume flow measuring unit - Flow optimization - Additive manufacturing (AM) or 3D printing - Selective laser melting (SLM)
Advanced lithographies for single-bacteria trapping
Single-cell analysis gives important insights into heterogeneity among cells and will be beneficial to cancer research, regenerative medicine and pharmaceutical development. A 3D-printer at the nanoscale will be used to produce micron-sized masters of wells for capturing single bacteria.
Automatic cardiac segmentation: how much labelled data do we really need?
In this Master project the student will investigate novel semi-supervised machine learning techniques for the automatic delineation (also known as segmentation) of cardiac MRI structures. Specifically, the project will be focused on new ideas from the field of neural networks and deep learning.
Sex chromosome evolution in liverworts
Evolution of sex chromosomes is poorly known in organisms in which sex is expressed in the haploid phase. This research project is intended to reveal the origin and evolutionary trajectory of sex chromosomes in liverworts using evolutionary genomic analysis.
Competing for nutrition: effect of iron starvation on cancer cells
Recently, historic efforts to harness living organisms to fight cancer have been revived via synthetic biology. Certain circulating bacteria can inherently locate tumors, and be engineered to controllably induce local cytotoxicity while remaining unobtrusive to the host system. A certain strain of b
Optimization of control loops in an ex vivo liver perfusion system
Keeping a liver viable outside the body.
Molographic immunosignaturing for next generation diagnostics
Early diagnosis is a crucial aspect of effective treatment and prevention of diseases. In this Masterthesis you will combine a new sensing technique called molography with immunosignaturing to create a biosensor capable of early disease detection.
PhD student position, human fetal neuroimaging and image processing research
The project will take place in a unique interdisciplinary environment that merges fetal MRI research, computer science and clinical neurosciences.
Enable ANYmal to see: Evaluation and Modeling of 3D Depth Sensors
Mobile robot navigation requires a robot to perceive its surroundings while moving through previously unseen environments. This project explores 3D depth sensors that provide the means to spatially capture the terrain and objects around the robot.
Pesticide policies - adding a spatial dimension
Pesticide use has negative effects on the environment and human health. Impact is though often dependent on landscape characteristics - effective and efficient pesticide policies should therefore consider such characteristics.
Novel ultrasound sensor in patient specific heart models
The sensor should be tested for robustness in patient specific hearts. The thesis involves experimentation and signal processing.
Amygdala oscillations in fear conditioning
Fear conditioning is a form of aversive associative learning that relies on synaptic plasticity in the amygdala and involves theta and gamma oscillations in this process (Seidenbecher et al. 2003, Science, Stujenske et al. 2014, Neuron). In this project, you will analyse human data.
High-precision measurements of human fear memory
Human fear memory research is challenging. Fear memory is measured via physiological readouts that are inherently noisy (e.g. ECG, pupil size, skin conductance). In this project, you will develop high-precision measurements of human fear memory by combining multiple readouts.
Crystal-melt reaction within the lower oceanic crust II
Magma batches underplate, ascend, stall and erupt along oceanic spreading ridges. Igneous complexes are characterised by FC and MASH processes. You will run fractional crystallization experiments to determine the liquid line of descent of mantle-derived melt.
Crystal-melt reaction within the lower oceanic crust I
Magma batches underplate, ascend, stall and erupt along oceanic spreading ridges. Igneous complexes are characterised by FC and MASH processes. You will examine crystal-scale records of partial melting in lower crust gabbroic cumulates from the Pacific fast-spreading ridge.
Simulation and Mechanical Testing for 3D Printed Tissue Scaffolds
Purpose is to leverage emerging 3D printing technologies to develop superior scaffold structures for regenerative medicine applications.
Detection, Pose Estimation and Manipulation of Arbitrarily Shaped Objects
Depending on student's interest and background there are multiple available projects within the scope of mobile manipulation project described below.
Feedback control of a syringe infusion pump
Design a feedback controller for a syringe infusion pump
Protocol development for assays of bone and cartilage tissues from mouse knee joints
Abstract: Reproducibly extracting and measuring biomarkers from small structures (e.g. mouse knees) can be challenging. The goal of this work is to develop protocols for this challenge.
Image processing of computed tomography data for quantitative assessment of joint health
Abstract: Joints are a primary target of destructive processes like arthritis, which can cause damage to bone and loss of function. Data captured with micro-computed tomography is used to understand disease and develop clinical solutions.
Developing biomechanical tools for cartilage & arthritis studies
Abstract: Arthritis is a musculoskeletal disease affecting around 500 million people worldwide. This disease, which is seen in many forms, is a painful though nonfatal, and results in high costs to society.
Contrast agents for micro-computed tomography (microCT) imaging of soft biological tissues and scaffold materials
Abstract: In tissue-engineering it is important to be able to monitor newly-forming tissue, and good imaging techniques are required to visualise this. One method, is the use of contrast agents to stain the scaffold material on which the new tissue will grow.
Experimental Human Knee Joint Impedance Estimation
Variable impedance actuators are used in many gait assistive devices. However, the unimpaired human knee joint impedance is unknown. This project will use an existing actuated knee brace to estimate the joint's impedance throughout the gait cycle.
Biomedical 3D-Printing: Computational Design and Rapid Prototyping
Stereolithography 3d-printing processes can construct high resolution structures at low cost. There is a great opportunity for prototyping parts with small-scale features or multiple interacting materials to generate interesting mechanical behaviors for biomedical products.
Master Thesis: Computational modeling and simulation of flow and transport in the Kidney
The kidneys are responsible for filtration of blood and removal of waste products of metabolism. To date, kidney O2 regulation is poorly understood. With the help of computational methods and using the latest supercomputers, we aim to determine oxygen distribution in the kidney.
Handheld biosensing device for readout of molographic signals
Portable or point-of-care is an indispensable feature of novel biosensor concepts in order to detect various diseases at home in an early stage. At LBB, we investigate a new diffractive optical biosensor concept - Focal Molography. This project aims at developing a miniaturized readout device.
New concepts of digitally fabricated heat distribution systems for building applications are explored. Heat distribution and temperature control in a 3D printed sand heat pipe will be investigated by experiments and simulations.
Body-on-a-chip: Automatization of 3D microtissue handling and analysis in microfluidic systems
3D spheroids are becoming increasingly important as in vitro models. Culturing them in microfluidic chips offers a wide variety of experimental applications. The project aims to automatize the experimental workflow with 3D spheroids in microfluidic chips, using sophisticated liquid handling robots.
Learning for Trajectory Optimization
Development of a learning algorithm that predicts a near-optimal solution to a trajectory optimization problem for robot locomotion.
Ultra‐thin and lightweight hybrid photovoltaic/thermal (PVT) collectors have been developed to facilitate building integration while minimizing costs. Within this thesis, integration of the PVT collector into a façade will be studied.
Evaluation of Spatial Overlay Statistics for Use in Landscape Genetics
The aim of this Master thesis is to evaluate whether spatial overlap statistics is a suitable way to include statistical testing in spatial overlays. For this aim, theory has to be reviewed and various existing landscape genetic data sets on animals should be tested.
Product Development for Nepal
The extraction of carrot seeds is an extensive and time-consuming work. The Thesis aims to develop a low-cost solution facilitating the process of seed extraction. The work, which is in Cooperation with Helvetas, includes needfinding in Nepal and the development of a technical concept in Zürich.
An economic valuation of the effect of climatic extremes on grassland yields and the role of species diversity.
The thesis aims to give insights into the reaction of grasslands to climatic extremes, with focus on the role of SD. Further it should be assessed what altering SD implies for farmers’ utility.
Rational texturing of metal surfaces for enhanced dropwise condensation under vapor flow
Condensation is a process found extensively in nature and technology. In this project employing fundamentals in wettability engineering we promote dropwise condensation (DWC) which exhbits much better heat transfer performance as compared to filmwise condensation (FWC).
Robotic Scene Understanding with Deep Semi-Supervised Learning
The goal of this project is implementing, developing and evaluating a machine learning system for robotic scene understanding over time from multiple sensor modalities.
Method to generate input data for high-fidelity noise emission model of an airliner
Based on airframe and propulsion models, the required input parameters for a high-fidelity noise emission model can be computed. Using flight trajectories obtained from secondary radar data and take-off mass for departures as input, the flight states and the thrust setting shall be estimated.
Evaluation of adhesion strategies for intervertebral disk repair via electrospun polycaprolactone scaffolds
The project is placed in the scope of a larger study on inter-vertebral disc regeneration. Small defects in intevetebral disks often lead to further degradation and a need for complete replacement of the organ. To allow for self healing of larger defects a support structure of electrospun polycapro
Simulation and Control in Drake
The aim of this project it to make use of the advanced capabilities of Drake in simulation and control for manipulation and locomotion under contacts.
MRI imaging of cerebrovascular alternations in mouse model of Alzheimer's disease
In this project, student will investigate the cerebrovascular and pathological alternations in brain of transgenic mouse model of Alzheimer's disease using high-resolution MRI.
Learning Ground Contact Detection for a Quadrupedal Robot
Implementation of a learning algorithm that detects ground contact for each foot. The learning approach should be independent of the gait and without knowledge of the mechanical properties of the robot.
Drawing European silver fir’s ecological species distribution map
Accurate species distribution data are essential for many ecological, evolutionary, and conservation related research. Your task will be defining the distribution range of silver fir across the Western Alps and the Apennines, along with describing the forest types where the species appears.
Improving hand function after stroke: Training of cooperative hand movements
We are developing a novel approach to improve hand function after stroke using a recently developed device. Pilot studies have shown promising results. This Master Thesis project will extend this work to severely affected stroke patients.
Additive Manufacturing of Silicone – 3D Printer Development
Many industries show great interest in Additive Manufacturing of silicone thanks to its versatile applications ranging from biomedical implants to soft robotics. Despite this great interest, 3D printing of elastomeric materials has long been a challenge in AM due to their viscous nature.
R&D Praktikum Process Engineering Packaging
Ihre Chance: Sammeln Sie erste Berufserfahrung und lernen Sie die tägliche Arbeit eines Prozessingenieurs kennen. Sie erhalten Einblick in die Schnittstelle zwischen Forschung & Entwicklung und der Produktion eines marktführenden Hightech-Unternehmens und legen so den Grundstein für Ihre persönliche Entwicklung.
Master project on biosensor development
Master project on biosensor development
Identification of the AML and ALC1/CHD1L (oncogene)- specific cellular ADP-ribosylome
In this project, we will study the ADP-ribosylated proteome of an AML cancer cell line and we will study the role of the oncogene product ALC1/CHD1L which can interact with proteins carrying this post-translation modification.
Sensing and control comparison for a mobile manipulator
The goal of this project is to investigate how design choices in the sensing and control system for a mobile manipulator impact system performance in tracking desired trajectories in Cartesian space.
Impedance–based Measurements in Microfluidic Platforms
we aim to use integrated electrodes in microfluidic platform as sensors for label free detection of growth of cells and small molecules secreted by cells/tissues. The integration of microfluidics and EIS would allow automated characterization of a wide range of compounds and their influence on cells
Effects of pesticide use on the provision of ecosystem services
Ecosystems provide important services to society. The use of pesticides though might reduce provision of such services. Possible effects have to be identified and to be accounted for in pesticide policies.
Multi-Channel Surface Plasmon Resonance System
Candidates will learn to perform different assays on the SPR system as well as get an introduction to the technical background. Furthermore, they will learn theoretical details about the SPR measurement technique.
The use of meta-analyses to evaluate and map ecosystem services
Meta-analyses seem to be an interesting alternative to overcome the lack of data available to assess ecosystem services. A state of the art of research on the use of meta-analysis would be of interest to identify gaps and contributions of such approachs.
Practice of ecosystem services valuation and mapping in the scientific literature.
Economic valuation is one of the many approaches possible to quantify and map ecosystem services are possible. Identifying and describing current state-of-the-art regarding the place of economic valuation in ecosystem services quantification and mapping should help to get a clear understanding of the contributions of such approaches and to highlight research gaps.
What can Smartphone Apps learn about their Users, using Big Data and Machine Learning?
Our vision is to create smartphone apps that know their users well and can therefore support them with their personal development goals or dealing with chronic illness. Are you interested in exploring how well exactly your smartphone could get to know you?
Student/in für 3-monatiges Forschungspraktikum am Exercise Physiology Lab gesucht
Für ein aktuelles Forschungsprojekt zum Thema “Decremental exercise protocol as a training stimulus: more or less efficient than traditional high-intensity interval training?” suchen wir ein/e motivierter/e Praktikant/in.
A Micro Opto-Fluidic Device for Laser Osteotomy
In this project, the Master candidate will support our interdisciplinary team in the development of a 3D printed microfluidic device for irrigation. One of the most efficient laser ablation mechanisms is thermal vaporization. In order that this process will be effective one has to create a controlle
Economic valuation of Ecosystem Services in the Parc Jura Vaudois
Economic valuation provides information on option and non-use values of landscapes for decision-makers, local organizations and the public. In this thesis, a choice experiment should reveal the willingness to pay of the local population for ecosystem services in the Parc Jura Vaudois (CH).
Food and food availability of Eurasian woodcock in the Jura Mountains
The thesis aims at identifying the food items of woodcocks in the breeding season and investigating their availability. The factors affecting food availability might be responsible for home-range placement as well as habitat use within home-ranges.
Assessing the dynamics in rural landscapes using remote sensing data: the base for understanding red kite foraging patterns
This thesis aims at combining open-access satellite imagery of different spatial and temporal scales to develop a landscape model identifying agricultural events.
Spatially explicit demography in a little owl population: mapping the fitness landscape
The aim of this master thesis is to link demographic data to space use data of little owl in order to identify landscape heterogeneity in reproductive success.
Determinants of stopover locations during migration in Red Kites
The aim of this Master thesis is to determine the most important environmental variables associated with stopover sites along the migratory trajectory of Red Kites compared to environmental variables “on the move”.
Use of conspecific attraction to influence the breeding habitat selection of Whinchat – Master thesis
The aim of this master thesis is to test whether an experimentally simulated presence of whinchats affects their breeding habitat selection, and how habitat selection is influenced by the interaction of experimentally elicited social attraction and other factors, such as habitat quality.
Numerical Modeling of the Core-to-Facesheet Interface Bond in Composite Lattice Core Sandwich Structures
To improve a numerical model for composite lattice core sandwich structures with respect to its capability to predict interface failure, the goal of this thesis is to develop an efficient numerical model for the core-to-facesheet interface bond in such ultra-lightweight structures.
PhD student position, Spatio-Temporal Modeling of Dialect Change with GIScience methods
We seek applicants for a PhD student position, focusing on how languages – in particular dialects – change over space and time and how such changes can be quantitatively modeled. We are looking for a highly motivated, original thinker, with a passion for science.
Development of Impedance Controller for the VariLeg Exoskeleton
VariLeg is an exoskeleton designed to enable paraplegics to walk over natural terrain and everyday obstacles. After training intensively for multiple months, the VariLeg team and one of their two paraplegic pilots successfully participated in the Cybathlon 2016.
Internship Opportunity in the VariLeg exoskeleton project (unpaid)
VariLeg is an exoskeleton designed to enable paraplegics to walk over natural terrain and everyday obstacles. After training intensively for multiple months, the VariLeg team and one of their two paraplegic pilots successfully participated in the Cybathlon 2016.
Robotic Endoscope for Laser Osteotomy
In this project, you will support our interdisciplinary team in stabilizing and controlling the end-effector of a robotic endoscope which is guided by a serial robot.

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